Facts about Aduro:
Aduro is a medical food for the dietary management of burn injuries and wound care to help promote new tissue growth. Aduro is comprised of 3 main ingredients all of which have proven to be beneficial in tissue growth and wound healing. Aduro is currently only available through a specific mail-order pharmacy, APS Pharmacy (888)547-2654.
Important Safety Information
Aduro is manufactured and distributed in accordance with strict Food and Drug Administration (FDA) guidelines. This medical food product is administered under supervision of a licensed healthcare professional and dispensed by prescription only. It can be taken alone or with commonly prescribed wound care medications. In addition, the main ingredients in Aduro has achieved self-affirmed Generally Recognized As Safe (GRAS) designation, the highest standard of safety for foods. Other ingredients are also GRAS or are FDA-approved food additives.
The 3 active ingredients have been studied in several clinical trials involving burn and wound care patients. Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls. Coudray-Lucas C, Le Bever H, Cynober L, De Bandt JP, Carsin H. Source: Laboratoire de Biologie de la Nutrition, Faculté des Sciences de Pharmacie et de Biologie, Paris, France.
OBJECTIVE:To compare the effectiveness on wound healing time in severe burn patients of ornithine alpha-ketoglutarate supplementation of enteral feeding vs. an isonitrogenous control. Previous clinical and experimental studies suggest a beneficial effect of enterally administered ornithine alpha-ketoglutarate supplementation on protein metabolism in burn patients, but few data deal with clinical outcome.
PATIENTS:Forty-seven severe burn patients with total burned body surface areas of 25% to 95% and presence of full thickness burn who were prescribed early exclusive enteral nutrition. Either ornithine alpha-ketoglutarate or isonitrogenous control (soy protein mixture, Protil-1) were administered twice a day as a bolus (2 x 10 g) at 9 am and 9 pm for 3 wks. The patients were evaluated for wound healing time (primary end point), antibiotic use, tolerance, duration of enteral nutrition, and nutritional status.
CONCLUSIONS:Ornithine alpha-ketoglutarate supplementation of enteral feeding significantly shortens wound healing time in severe burn patients. In addition, ornithine alpha-ketoglutarate administration was safe and well tolerated and decreased protein hypercatabolism in the less severe burn patients.
The Effect of Oral L-glutamine on the Healing of Second-degree Burns in Mice
Author(s): Mohammad Jalilimanesh, MD; Hassan Mozaffari-Khosravi, PhD; Maryam Azhdari, MSc
Several studies have evaluated the effect of glutamine and glutamate supplementation in enteral nutrition for hypercatabolic states (eg, burn injuries), and have shown that glutamate could be a substitute for glutamine.7 Some studies have shown that glutamine enhances the ability of neutrophils to destroy bacteria,8 while some studies failed to show any effects in wound healing.9,10 In burn injuries, reduction of plasma and muscular glutamine with muscular wasting, weight loss, and infection occur. Vitamin C and human wound healing.
Ringsdorf WM Jr, Cheraskin E.
Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA). The authors administered daily dosages of 500 to 3,000 mg., which is roughly 8 to 50 times the RDA of 60 mg., to subjects recovering from surgery, other injuries, decubital ulcers, and leg ulcers induced by hemolytic anemia. Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. Four grams of ascorbic acid daily produced a significant improvement in the quality of newly synthesized collagen but did not alter that formed prior to the supplementation of C. The combined evidence in this review provides a substantial base for further research, both clinical and experimental trials, concerning the interrelationships between vitamin C and the body's healing potential. Recent Advances in the Nutritional Care of Burn Patients